Acamprosate calcium is an agonist of GABA receptor. It can act as a modulator of glutamatergic systems and reduce alcohol consumption in animal models of alcohol addiction.
Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. Acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol[3]. Acamprosate calcium may be effective augmentation therapy in patients with treatment-resistant anxiety[4]. Acamprosate and naltrexone are established strategies for pharmacologic relapse prevention in patients with alcohol dependence. The combined treatment with both agents should be considered in patients who did not achieve abstinence under monotherapy unless contraindications are present[5]. Moreover, acamprosate (200 mg/kg) may induce antidepressant-like effect and that NMDA and mGlu5 receptors are crucial targets of acamprosate in this action[6].
United States, Illinois
... 展开 >>
Rush University Medical Center
Chicago, Illinois, United States, 60612
United States, New York
North Shore University Hospital, Dept. of Psychiatry
Manhasset, New York, United States, 11030 收起 <<
Germany
... 展开 >> Department of Psychiatry, University of Regensburg
Regensburg, Bayern, Germany, 93053
Department of Psychiatry, University of Freiburg
Freiburg, BW, Germany, 79104
Department of Psychiatry, University of Heidelberg
Heidelberg, BW, Germany, 69115
Department of Addictive Behavior und Addiction Medicine, Central Institute of Mental Health
Mannheim, BW, Germany, 68159
Department of Psychiatry, University of Tübingen
Tuebingen, BW, Germany, 72076 收起 <<
United States, Connecticut
... 展开 >>
Substance Abuse Treatment Unit, Yale University
New Haven, Connecticut, United States, 06511
United States, Florida
University of Miami School of Medicine
Miami, Florida, United States, 33136
United States, Massachusetts
Harvard University/McLean Hospital
Belmont, Massachusetts, United States, 02478
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Boston University School of Medicine
Boston, Massachusetts, United States, 02118
United States, New Mexico
Center on Alcoholism, Substance Abuse and Addiction, University of New Mexico
Albuquerque, New Mexico, United States, 87106
United States, Pennsylvania
Treatment and Research Center, University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, Rhode Island
Roger Williams Medical Center , Brown University
Providence, Rhode Island, United States, 02908
United States, South Carolina
Center for Alcohol Programs, Medical University of South Carolina
Charleston, South Carolina, United States, 29425
United States, Texas
Southwest Texas Addiction Research and Technology Center, University of Texas Health Science Center
San Antonio, Texas, United States, 78229
United States, Washington
Addictions Treatment Center, University of Washington
Seattle, Washington, United States, 98108
United States, Wisconsin
University of Wisconsin-Milwaukee
Milwaukee, Wisconsin, United States, 53233 收起 <<
Germany
... 展开 >> Department of Psychiatry and Psychotherapy at the Heinrich-Heine-University Düsseldorf, Rhineland State Clinics Düsseldorf, Bergische Landstraße 2, 40629 Düsseldorf, Germany
Düsseldorf, North Rhine-Westfalia, Germany, 40629 收起 <<
United States, South Carolina
... 展开 >>
Institute of Psychiatry, Medical University of South Carolina
Charleston, South Carolina, United States, 29425 收起 <<
United States, South Carolina
... 展开 >>
Institute of Psychiatry, Medical University of South Carolina
Charleston, South Carolina, United States, 29425 收起 <<
Alcohol Dependence
... 展开 >> Major Depression
Social Anxiety Disorder
Generalized Anxiety Disorder 收起 <<
Phase 4
Completed
-
United States, Massachusetts
... 展开 >>
McLean Hospital
Belmont, Massachusetts, United States, 02478
United States, New York
Columbia University College of Physicians & Surgeons
New York, New York, United States, 10025
United States, South Carolina
Behavioral Health Services of Pickens County
Pickens, South Carolina, United States, 29671 收起 <<
United States, New Mexico
... 展开 >>
University of New Mexico
Recruiting
Albuquerque, New Mexico, United States, 87131-0001
Contact: Florian Birkmayer, M.D. 505-272-2223 fbirkmayer@salud.unm.edu
Sub-Investigator: Michael Bogenschutz, M.D. 收起 <<
United States, Illinois
... 展开 >>
Rush University Medical Center
Recruiting
Chicago, Illinois, United States, 60612
Contact: Jamie Chin 312-942-0025 jamie_a_chin@rush.edu
Principal Investigator: Elizabeth Berry-Kravis, MD
United States, Ohio
Cincinnati Children's Hospital Medical Center
Recruiting
Cincinnati, Ohio, United States, 45229
Contact: Katie Friedmann, RN 513-636-0523 fragilex@cchmc.org
Principal Investigator: Craig Erickson, MD 收起 <<
United States, North Carolina
... 展开 >>
UNC Family Medicine Center
Chapel Hill, North Carolina, United States, 27599
United States, Wisconsin
Center for Addiction and Behavioral Health Research University of Wisconsin-Milwaukee
Milwaukee, Wisconsin, United States, 53211 收起 <<
United States, Maryland
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VA Maryland Health Care System
Baltimore, Maryland, United States, 21201
Keypoint Community Mental Health Centers- Dundalk
Baltimore, Maryland, United States, 21222
Keypoint Community Mental Health Centers- Catonsville
Baltimore, Maryland, United States, 21228
Maryland Psychiatric Research Center
Baltimore, Maryland, United States, 21228 收起 <<
United States, Indiana
... 展开 >>
Riley Child and Adolescent Psychiatry Clinic - Riley Hospital for Children
Indianapolis, Indiana, United States, 46202 收起 <<
United States, Ohio
... 展开 >>
Cincinnati Children's Hospital Medical Center
Recruiting
Cincinnati, Ohio, United States, 45229
Principal Investigator: Craig A Erickson, MD 收起 <<
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