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描述 | AZ1495 is a potent, orally active inhibitor of IRAK4. AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively. The Kd value for IRAK4 inhibition by AZ1495 is 0.0007 μM. AZ1495 inhibits IRAK4 with a Kd value of 0.0007 μM in the concentration range of 0.001-100 μM. In the range of 0.001-100 μM, AZ1495 inhibited NF-κB activation and the growth of ABC-DLBCL cell line in a dose-dependent manner for 72 hours. At concentrations less than 3.3 μM for 14 hours, AZ1495 completely inhibited NF-κB signalling, and at lower concentrations in combination with BTK inhibitors induced OCI-LY10 cell death[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.59mL 0.52mL 0.26mL |
12.97mL 2.59mL 1.30mL |
25.94mL 5.19mL 2.59mL |
CAS号 | 2196204-23-4 |
分子式 | C21H31N5O2 |
分子量 | 385.5 |
SMILES Code | C12=NC=NC(N[C@H]3CC[C@H](N4CCOCC4)CC3)=C1C(C5CCOCC5)=CN2 |
MDL No. | MFCD31813626 |
别名 | |
运输 | 蓝冰 |
InChI Key | DJVYXMINSBMUHH-UHFFFAOYSA-N |
Pubchem ID | 131839619 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Keep in dark place, sealed in dry, 2-8°C |
溶解方案 |
请根据您的动物给药指南选择适当的溶解方案。 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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