货号:A834543
同义名:
NSC 31171; N-xanthen-9-yl-p-Toluenesulfonamide
AH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist with pIC50 of 7.1 for human FFA4.
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描述 | AH-7614 demonstrates potent and selective antagonism against FFA4 (GPR120), with pIC50 values of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. It exhibits selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 effectively inhibits the actions of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist[1].[2]. |
Animal study | AH7614 (50 μg; intratumoral injection once every 4 days for 20 days) decreases tumor growth in mice[3].AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to chemotherapy and inhibits tumor progression by blocking GPR120 signaling in combination with Epirubicin[3]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.85mL 0.57mL 0.28mL |
14.23mL 2.85mL 1.42mL |
28.46mL 5.69mL 2.85mL |
CAS号 | 6326-06-3 |
分子式 | C20H17NO3S |
分子量 | 351.42 |
SMILES Code | CC(C=C4)=CC=C4S(NC2C3=C(C=CC=C3)OC1=CC=CC=C12)(=O)=O |
MDL No. | MFCD00379273 |
别名 | NSC 31171; N-xanthen-9-yl-p-Toluenesulfonamide |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry, 2-8°C |