9-Aminocamptothecin | 9-Amino-20(S)-camptothecin | Topoisomerase I Inhibitor

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9-Aminocamptothecin/9-氨基喜树碱 {[allProObj[0].p_purity_real_show]}

货号：A432426 同义名： 9-Amino-20(S)-camptothecin; 9-Amino-CPT

9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.

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9-Aminocamptothecin/9-氨基喜树碱化学结构
CAS号：91421-43-1

9-Aminocamptothecin/9-氨基喜树碱 3D分子结构
CAS号：91421-43-1

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9-Aminocamptothecin/9-氨基喜树碱纯度/质量文件产品仅供科研

货号：A432426 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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拓扑异构酶亚型比较

产品名称	Topo I ↓ ↑	Topo II ↓ ↑	Topo IV ↓ ↑	Topoisomerase ↓ ↑	其他靶点	纯度
Ellagic acid	✔					98%
β-Lapachone	✔					99%+
(s)-10-hydroxycamptothecin	✔					98+%
Camptothecin	++ Topo I, IC50: 0.68 μM					98%
Betulinic acid	++ Eukaryotic topoisomerase I, IC50: 5 μM					98%
Topotecan	++++ Topo I (DU-145 Luc cells), IC50: 2 nM Topo I (MCF-7 Luc cells), IC50: 13 nM					98%
Irinotecan HCl Trihydrate	✔					98%
SN-38	✔					98%
Levofloxacin hydrate		✔				98%
Dexrazoxane		✔				99%+
Ofloxacin		✔				98+%
Enoxacin		✔				99%+
Flumequine		+ Topo II, IC50: 15 μM				98%
Levofloxacin		✔				97%
Etoposide		✔				98%
Pefloxacin mesylate dihydrate		✔				99+%
Marbofloxacin		✔				98+%
Voreloxin HCl		✔				98%
Mitoxantrone 2HCl		✔			PKC	98%
Nalidixic acid		✔				98%
Doxorubicin		✔				97%
Novobiocin sodium		✔				95%
Amonafide		✔				99%+
Pirarubicin		✔				98%+
Idarubicin HCl		+++ Topo II (MCF-7 cells), IC50: 3.3 ng/mL				99%+
Genistein		✔			EGFR	98%
Teniposide		✔				98%
Moxifloxacin		✔				98%
Ciprofloxacin			✔			98%
Clinafloxacin			✔			99%
Gatifloxacin				✔		98%
Daunorubicin HCl				+++ DNA synthesis, Ki: 20 nM		98%
Epirubicin HCl				✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

9-Aminocamptothecin/9-氨基喜树碱生物活性

描述

9-Aminocamptothecin, an inhibitor of topoisomerase I, exhibits strong anticancer properties. In cancer cell lines from such as breast (MCF-7), bladder (MGH-U1), and colon (HT-29), the cytotoxic effects of 9-Aminocamptothecin escalate with increased drug concentrations and prolonged exposure periods. Notably, minimal cell death occurs unless the concentration of 9-Aminocamptothecin surpasses a threshold of 2.7 nM^[1]. 9-Aminocamptothecin demonstrates inhibition of PC-3, PC-3M, DU145, and LNCaP cells, with IC50 values of 34.1 nM, 10 nM, 6.5 nM, and 8.9 nM respectively, following a drug exposure period of 96 hours^[2].

9-Aminocamptothecin/9-氨基喜树碱临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00003551	Kidney Cancer	Phase 2	Completed	-	United States, Georgia ... 展开 >> Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 Emory University School of Medicine Atlanta, Georgia, United States, 30322 收起 <<
NCT00003523	Ovarian Cancer ... 展开 >> Primary Peritoneal Cavity Cancer 收起 <<	Phase 2	Completed	-	-
NCT00002635	Lymphoma	Phase 2	Completed	-	United States, Connecticut ... 展开 >> Yale Comprehensive Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Illinois Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts New England Medical Center Hospital Boston, Massachusetts, United States, 02111 收起 <<

9-Aminocamptothecin/9-氨基喜树碱参考文献

[1]Maier-Salamon A, Thalhammer T, et al. Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86.

[2]Gao SQ, Sun Y, et al. Antitumor efficacy of colon-specific HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromol Biosci. 2009 Nov 10;9(11):1135-42.

9-Aminocamptothecin/9-氨基喜树碱实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.52mL

5.50mL

2.75mL

9-Aminocamptothecin/9-氨基喜树碱技术信息

CAS号	91421-43-1
分子式	C₂₀H₁₇N₃O₄
分子量	363.37
SMILES Code	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(N)C=CC=C5N=C4C3=C2)=O
MDL No.	MFCD00909855

别名	9-Amino-20(S)-camptothecin; 9-Amino-CPT; NSC 603071; Aminocamptothecin; 9-AC
运输	蓝冰
InChI Key	FUXVKZWTXQUGMW-FQEVSTJZSA-N
Pubchem ID	72402

存储条件	In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00003551	Kidney Cancer	Phase 2	Completed	-	United States, Georgia ... 展开 >> Emory University Hospital - Atlanta Atlanta, Georgia, United States, 30322 Emory University School of Medicine Atlanta, Georgia, United States, 30322 收起 <<
NCT00003523	Ovarian Cancer ... 展开 >> Primary Peritoneal Cavity Cancer 收起 <<	Phase 2	Completed	-	-
NCT00002635	Lymphoma	Phase 2	Completed	-	United States, Connecticut ... 展开 >> Yale Comprehensive Cancer Center New Haven, Connecticut, United States, 06520-8028 United States, Illinois Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611 United States, Massachusetts New England Medical Center Hospital Boston, Massachusetts, United States, 02111 收起 <<
NCT00003154	Lung Cancer	Phase 2	Completed	-	United States, Ohio ... 展开 >> Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 收起 <<
NCT02646189	Hepatitis B, Chronic	Phase 1 Phase 2	Completed	-	Bangladesh ... 展开 >> Farabi General Hospital Dhaka, Bangladesh, 1213 收起 <<
NCT00002745	Lymphoma	Phase 2	Completed	-	United States, District of Col... 展开 >>umbia Walter Reed Army Medical Center Washington, District of Columbia, United States, 20307-5000 United States, Minnesota University of Minnesota Cancer Center Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington University Barnard Cancer Center Saint Louis, Missouri, United States, 63110 United States, New Jersey Cooper Cancer Institute Camden, New Jersey, United States, 08103 St. Joseph's Hospital and Medical Center Paterson, New Jersey, United States, 07503 收起 <<
NCT00003192	Esophageal Cancer ... 展开 >> Gastric Cancer 收起 <<	Phase 2	Completed	-	United States, Illinois ... 展开 >> University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Cancer Care Specialists of Central Illinois, S.C. Decatur, Illinois, United States, 62526 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46617 收起 <<
NCT00251368	Leukemia, Myelocytic, Acute ... 展开 >> Acute Lymphocytic Leukemia 收起 <<	Phase 1	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hosptial Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<
NCT00002671	Ovarian Cancer	Phase 2	Completed	-	United States, New Jersey ... 展开 >> Riverview Medical Center Red Bank, New Jersey, United States, 07701 Overlook Hospital Summit, New Jersey, United States, 07902-0220 United States, New York Albert Einstein Comprehensive Cancer Center Bronx, New York, United States, 10461 NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 New York Presbyterian Hospital - Cornell Campus New York, New York, United States, 10021 Mount Sinai Medical Center, NY New York, New York, United States, 10029 收起 <<
NCT00001427	Ovarian Neoplasms	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 收起 <<
NCT02646163	Hepatitis B, Chronic	Phase 1 Phase 2	Completed	-	Bangladesh ... 展开 >> Farabi General Hospital Dhaka, Bangladesh, 1213 收起 <<

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