货号:A677127
同义名:
GTPL5846; 6-n-octylaminouracil
6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
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产品名称 | ERK ↓ ↑ | ERK1 ↓ ↑ | ERK2 ↓ ↑ | ERK5 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DEL-22379 |
+
ERK, IC50: 0.5 μM |
+
ERK, IC50: 0.5 μM |
98% | ||||||||||||||||
Pluripotin |
++
ERK1, Kd: 98 nM |
RasGAP | 98+% | ||||||||||||||||
FR 180204 |
+
ERK1, Ki: 0.31 μM |
++
ERK2, Ki: 0.14 μM |
98% | ||||||||||||||||
Ravoxertinib |
+++
ERK1, IC50: 1.1 nM |
++++
ERK2, IC50: 0.3 nM |
99%+ | ||||||||||||||||
SCH772984 |
+++
ERK1, IC50: 4 nM |
++++
ERK2, IC50: 1 nM |
99%+ | ||||||||||||||||
Temuterkib |
+++
ERK1, IC50: 5 nM |
+++
ERK2, IC50: 5 nM |
99%+ | ||||||||||||||||
VX-11e |
+++
ERK2, Ki: <2 nM |
99%+ | |||||||||||||||||
Ulixertinib |
++++
ERK2, IC50: <0.3 nM |
99%+ | |||||||||||||||||
XMD17-109 |
++
ERK5, IC50: 162 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | 6-OAU (GTPL5846) (6-n-octylaminouracil) functions as a GPR84 (G protein-coupled receptor 84) agonist with an EC50 of 105 nM. It attracts PMNs and macrophages, boosts IL-8 proinflammatory cytokine levels, indicating its proinflammatory effects. Additionally, 6-OAU has antibacterial capabilities[1][2]. |
Animal study | 6-OAU triggers GPR84, leading to the creation of an inflammatory state via chemokine production and chemotaxis in vivo[1].6-OAU (10 mg/kg; i.v.) elevates the blood CXCL1 concentration in rats[1].6-OAU (1 mg/mL; sC.) draws both PMNs and macrophages into the air pouch[1].6-OAU (2 μM, 100 mL/mouse; subcutaneously) enhances resistance to Brucella infection and diminishes bacterial growth in spleens and livers[2]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
4.18mL 0.84mL 0.42mL |
20.89mL 4.18mL 2.09mL |
41.79mL 8.36mL 4.18mL |
CAS号 | 83797-69-7 |
分子式 | C12H21N3O2 |
分子量 | 239.31 |
SMILES Code | O=C1NC(C=C(NCCCCCCCC)N1)=O |
MDL No. | MFCD28900678 |
别名 | GTPL5846; 6-n-octylaminouracil |
运输 | 蓝冰 |
InChI Key | PFSWASUQURIOOR-UHFFFAOYSA-N |
Pubchem ID | 10354234 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |