4-Methylumbelliferone | 4-甲基伞形酮 | Hymecromone | Hyaluronic Acid Biosynthesis Inhibitor

首页 / 抑制剂/激动剂 / 蛋白质酪氨酸激酶(Protein Tyrosine Kinase) / GAK / 4-Methylumbelliferone/羟甲香豆素

4-Methylumbelliferone/羟甲香豆素 {[allProObj[0].p_purity_real_show]}

货号：A132122 同义名： 4-甲基伞形酮 / Hymecromone; 4-MU

4-Methylumbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.

4-Methylumbelliferone/羟甲香豆素化学结构
CAS号：90-33-5

4-Methylumbelliferone/羟甲香豆素 3D分子结构
CAS号：90-33-5

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4-Methylumbelliferone/羟甲香豆素纯度/质量文件产品仅供科研

货号：A132122 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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4-Methylumbelliferone/羟甲香豆素生物活性

描述	4-Methylumbelliferone is an inhibitor of hyaluronic acid biosynthesis, displaying antitumoral and antimetastatic effects.

4-Methylumbelliferone/羟甲香豆素细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
293H DA cells		Function assay	16 h	Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assay, EC50=0.0024 μM	22582973
3T3L1 cell	1 uM	Function assay		Induction of mouse 3T3L1 cell differentiation assessed as increase in accumulation of intracellular lipid droplet at 1 uM by Oil red O staining	21401118
3T3L1 cells		Function assay	7 days	Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in lipid accumulation after 7 days by Oil red O staining	20527969
3T3L1 cells	10 uM	Function assay		Increase in adiponectin mRNA levels in TNFalpha-induced mouse 3T3L1 cells pretreated at 10 uM before TNF-alpha challenge relative to control	21851089

4-Methylumbelliferone/羟甲香豆素临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00304512	Fabry Disease	Phase 2	Completed	-	United States, Georgia ... 展开 >> Decatur, Georgia, United States, 30033 Australia, Victoria Parkville, Victoria, Australia, 3050 Brazil Porto Alegre, Brazil, RS, 90035-903 Canada Montréal, Canada, H4J 1C5 France Paris, France, 75015 United Kingdom Salford, United Kingdom, M6 8HD 收起 <<
NCT00214500	-		Completed	-	-
NCT00526071	Fabry Disease	Phase 2	Terminated(The Sponsor (Amicus... 展开 >> Therapeutics) terminated this study for logistical reasons.) 收起 <<	-	United States, Georgia ... 展开 >> Decatur, Georgia, United States, 30033 United States, New York New York, New York, United States, 10016 United States, Texas Dallas, Texas, United States, 78226 Australia Parkville, Australia Brazil Porto Alegre, Brazil France Garches, France United Kingdom London, United Kingdom Salford, United Kingdom 收起 <<

4-Methylumbelliferone/羟甲香豆素参考文献

[1]Nagy N, Kuipers HF, et al. 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 2015 Mar 23;6:123.

[2]Kuroda Y, Kasai K, et al. 4-Methylumbelliferone inhibits the phosphorylation of hyaluronan synthase 2 induced by 12-O-tetradecanoyl-phorbol-13-acetate. Biomed Res. 2013 Apr;34(2):97-103.

4-Methylumbelliferone/羟甲香豆素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.38mL

5.68mL

2.84mL

56.76mL

11.35mL

5.68mL

4-Methylumbelliferone/羟甲香豆素技术信息

CAS号	90-33-5
分子式	C₁₀H₈O₃
分子量	176.17
SMILES Code	O=C1C=C(C)C2=C(O1)C=C(O)C=C2
MDL No.	MFCD00006866

别名	4-甲基伞形酮 ;Hymecromone; 4-MU; Imecromone; 7-Hydroxy-4-methylcoumarin; 4-Methyl-7-hydroxycoumarin; 4-ΜU
运输	蓝冰
InChI Key	HSHNITRMYYLLCV-UHFFFAOYSA-N
Pubchem ID	5280567

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

293H DA cells		Function assay	16 h	Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assay, EC50=0.0024 μM	22582973
3T3L1 cell	1 uM	Function assay		Induction of mouse 3T3L1 cell differentiation assessed as increase in accumulation of intracellular lipid droplet at 1 uM by Oil red O staining	21401118
3T3L1 cells		Function assay	7 days	Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in lipid accumulation after 7 days by Oil red O staining	20527969
3T3L1 cells	10 uM	Function assay		Increase in adiponectin mRNA levels in TNFalpha-induced mouse 3T3L1 cells pretreated at 10 uM before TNF-alpha challenge relative to control	21851089
Ac2F cells	0.1 to 10 μM	Function assay	6 hrs	Agonist activity at PPARgamma in rat Ac2F cells assessed as luciferase activity at 0.1 to 10 uM after 6 hrs by reporter gene assay	22819190
BHK21 cells		Function assay		Agonist activity at human PPARgamma expressed in BHK21 cells assessed as SEAP activity by luciferase reporter transactivation assay, EC50=0.45 μM	19349176
BL21 cells		Function assay		Displacement of radio labeled 2(S)-(2-benzoyl-phenylamino)-3-{4-[1,1-ditritio-2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid from GST-fused human PPARgamma expressed in Escherichia coli BL21 cells by scintillation proximity assay, EC50=0.45 μM	19349176
BL21 DE3 cells		Function assay		Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by scintillation proximity assay, Ki=0.074 μM	22081932
C2C12 cells	30 μM	Function assay	2 h	Induction of 2-deoxy-[3H]-glucose uptake in mouse C2C12 cells at 30 uM after 2 hrs by liquid scintillation counting analysis	25835537
CHO-K1 cells		Function assay		Partial agonist activity at human PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay, EC50=0.1 μM	20527969
COS1 cells		Function assay		Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR gamma receptor, EC50=0.021 μM	12617924
COS1 cells		Function assay		Agonist activity at human recombinant PPARgamma expressed in COS1 cells co-expressing GAL4 assessed as transcriptional activity after 48 hrs by luciferase reporter gene assay, EC50=0.02 μM	19507861
COS1 cells		Function assay		Agonist activity at human PPARgamma receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation assay, EC50=0.02 μM	19530681
COS1 cells		Function assay	24 hrs	Transactivation of human full length PPARgamma expressed in COS1 cells co-transfected with RXRalpha after 24 hrs by luciferase reporter gene assay, EC50=0.12 μM	22197396
COS1 cells		Function assay		Binding affinity to human wild type PPARgamma LBD expressed in COS1 cells co-expressing GAL4 by scintillation proximity assay	22070604
COS-1 cells		Function assay		In vitro transactivation of human peroxisome proliferator activated receptor gamma measured in PPAR-GAL4 chimeric COS-1 cells, EC50=0.02 μM	12873517
COS-1 cells		Function assay		In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells, EC50=0.02 μM	12729668
COS-1 cells		Function assay	24 hrs	Agonist activity at human PPARgamma ligand binding domain expressed in COS-1 cells after 24 hrs by luciferase reporter gene-based luminometric analysis, EC50=0.048 μM	22051054
COS7 cells		Function assay		Agonist activity at human recombinant PPARgamma2 LBD expressed in african green monkey COS7 cells coexpressing GAL4 by luciferase reporter gene transactivation assay, EC50=0.1 μM	20138762
COS7 cells		Function assay		Agonist activity at human recombinant PPARgamma1 LBD expressed in african green monkey COS7 cells coexpressing GAL4 by luciferase reporter gene transactivation assay, EC50=0.03 μM	20138762
COS7 cells		Function assay		Modulation of human PPARgamma-LBD expressed in african green monkey COS7 cells co-transfected with Gal4 assessed as activation of transactivation activity by luciferase assay, EC50=0.043 μM	21873070
CV1 cells		Function assay		Transactivation of PPARgamma in CV1 cells, EC50=0.076 μM	16821769
CV1 cells		Function assay		Transactivation of human PPARgamma in CV1 cells by luciferase reporter gene assay, EC50=0.308 μM	16970391
CV1 cells		Function assay		Activity at human PPARgamma in CV1 cells, EC50=0.308 μM	17005394
CV1 cells		Function assay		Agonist activity at human PPARalpha in CV1 cells by GAL4 transactivation assay after 24 hrs, EC50=3.46 μM	17507225
CV1 cells		Function assay		Agonist activity at human PPARgamma in CV1 cells by GAL4 transactivation assay after 24 hrs, EC50=0.03 μM	17507225
CV1 cells		Function assay		Agonist activity at human PPARgamma expressed in CV1 cells by receptor transactivation assay, EC50=0.308 μM	18029178
CV1 cells		Function assay		Agonist activity at PPARgamma in CV1 cells by transactivation assay, EC50=0.308 μM	17129725
CV1 cells		Function assay		Agonist activity at human PPARgamma ligand binding domain expressed in african green monkey CV1 cells co-transfected with fused Gal4-DBD by transactivation assay, EC50=0.033 μM	18826205
CV1 cells		Function assay		Agonist activity at human PPARalpha ligand binding domain expressed in african green monkey CV1 cells co-transfected with fused Gal4-DBD by transactivation assay, EC50=3.46 μM	18826205
CV1 cells		Function assay		Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay, EC50=0.1 μM	21112784
CV1 cells		Function assay	40 h	Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay, EC50=0.1 μM	21515063
CV-1 cells		Function assay		Maximal reporter activity against human Peroxisome proliferator activated receptor gamma Gal4 chimeric in transiently transfected CV-1 cells by functional assay, EC50=0.043 μM	11720854
CV-1 cells		Function assay		Activation of peroxisome proliferator activated receptor gamma measured by induction of 50% of maximum alkaline phosphatase activity, transfection assay in CV-1 cells, EC50=0.08913 μM	9836620
CV-1 cells		Function assay		In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cells, EC50=0.06 μM	8576907
CV-1 cells		Function assay		In vitro evaluation against RXR-alpha/PPAR-gamma in CV-1 cells by cotransfection assay was determined, EC50=0.325 μM	12954061
DU145 cells		Cytotoxicity assay	48 hrs	Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay, EC50=16 μM	24996143
HEK cells		Function assay		Agonist activity at human GAL4-tagged PPARalpha chimeric receptor expressed in HEK cells by transactivation assay, EC50=10.58 μM	20299214
HEK cells		Function assay		Agonist activity at human GAL4-tagged PPARgamma chimeric receptor expressed in HEK cells by transactivation assay, EC50=0.035 μM	20299214
HEK293 cells		Function assay		Activity at human adipose tissue PPAR gamma expressed in HEK293 cells by PPAR-GAL4 transactivation assay, EC50=0.31 μM	17343371
HEK293 cells		Function assay		Agonist activity at PPARgamma receptor expressed in HEK293 cells by GAL4 transactivation assay, EC50=0.035 μM	17292606
HEK293 cells		Function assay		Agonist activity at PPARgamma expressed in HEK293 cells by GAL4 transactivation assay, EC50=0.19 μM	18029176
HEK293 cells		Function assay		Agonist activity at PPARgamma expressed in HEK293 cells assessed as aP2 gene induction, EC50=0.12 μM	18029176
HEK293 cells		Function assay		Agonist activity at PPARgamma in HEK293 cells by GAL4 transactivation assay, EC50=0.045 μM	18291645
HEK293 cells		Function assay	16 to 20 hrs	Transactivation of Gal4-fused human PPARgamma expressed in HEK293 cells after 16 to 20 hrs by luciferase reporter gene assay, EC50=0.043 μM	21128600
HEK293 cells	10 μM	Function assay		Transactivation of PPARgamma (unknown origin) expressed in HEK293 cells co-transfected with AP2-PPRE at 10 uM by luciferase reporter gene assay	23273519
HEK293 cells		Function assay		Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay, EC50=0.004 μM	23286787
HEK293 cells		Function assay	24 h	Transactivation of GAL4 DBD-fused human PPARgamma-LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assay, EC50=0.1 μM	23294830
HEK293 cells		Function assay	48 hrs	Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay, EC50=43.71 μM	23265844
HEK293 cells		Function assay		Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assay, EC50=0.01 μM	25305688
HEK293 cells		Function assay	24 hrs	Transactivation of PPARgamma (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter gene assay	25442322
HEK293 cells		Function assay	24 hrs	Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay, EC50=0.03 μM	24955889
HEK293 cells	10 μM	Function assay	24 hrs	Transactivation of PPAR-gamma (unknown origin) expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay	24890090
HEK293 cells	10 μM	Function assay	24 h	Agonist activity at PPARgamma (unknown origin) expressed in HEK293 cells assessed as receptor transactivation at 10 uM incubated for 24 hrs by luciferase reporter gene assay	26384286
HEK293T cells	1 μM	Function assay	24 hrs	Partial agonist activity at human PPARgamma-LBD expressed in HEK293T cells assessed as induction of receptor transactivation at 1 uM after 24 hrs by luciferase reporter gene assay	21030263
HeLa cells		Function assay		Agonist activity at PPARgamma ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay, EC50=0.015 μM	19275963
Hep G2 cells		Function assay		Agonist activity at human PPARgamma ligand binding domain expressed in human Hep G2 cells co-transfected with Gal4-DBD by luciferase reporter gene assay, EC50=0.04 μM	19053776
HepaR cells		Function assay	1 day	Agonist activity at PPARgamma in human HepaR cells assessed as increase in HMGCS2 gene expression at 1 uM incubated for 1 day by quantitative PCR method relative to untreated control	25497132
HepaR cells	1 uM	Function assay	1 day	Agonist activity at PPARgamma in human HepaR cells assessed as increase in ANGPTL4 gene expression at 1 uM incubated for 1 day by quantitative PCR method relative to untreated control	25497132
HepaR cells	1 uM	Function assay	1 day	Agonist activity at PPARgamma in human HepaR cells assessed as increase in FABP1 gene expression at 1 uM incubated for 1 day by quantitative PCR method relative to untreated control	25497132
HepG2 cells		Function assay		Effective concentration against human PPARgamma expressed in HepG2 cells, EC50=0.039 μM	16107150
HepG2 cells		Function assay		Agonist activity at human PPAR gamma in a HepG2 cells by PPAR-GAL4 transactivation assay, EC50=0.158 μM	16973358
HepG2 cells		Function assay		Agonist activity at human PPAR gamma in HepG2 cells by PPAR-GAL4 transactivation assay, EC50=0.158μM	16979341
HepG2 cells		Function assay		Agonist activity at human PPARgamma in HepG2 cells by PPAR-GAL4 transactivation assay, EC50=0.082 μM	17157019
HepG2 cells		Function assay		Agonist activity at human PPARalpha ligand binding domain expressed in human HepG2 cells co-transfected with Gal4 by luciferase reporter gene assay, EC50=0.039 μM	18835719
HepG2 cells		Function assay		Agonist activity at PPARgamma expressed in human HepG2 cells assessed as induction of receptor transactivation by reporter gene assay relative to control, EC50=0.05 μM	18625559
HepG2 cells		Function assay		Agonist activity at human PPARgamma expressed in HepG2 cells by GAL4 transactivation assay, EC50=0.223 μM	18394907
HepG2 cells		Function assay		Agonist activity at GAL4-tagged human PPARgamma ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation by luciferase reporter gene assay, EC50=0.039 μM	19775169
HepG2 cells		Function assay		Agonist activity at human PPARgamma expressed in HepG2 cells by GAL4 transactivation assay, EC50=0.223 μM	19783444
HepG2 cells	10 umol/L	Function assay	24 hrs	Increase in glucose consumption in human HepG2 cells at 10 umol/L after 24 hrs relative to control	21256748
HepG2 cells		Function assay		Agonist activity at PPARgamma receptor expressed in human HepG2 cells by PPRE-luciferase reporter gene assay, EC50=0.01 μM	21482446
HepG2 cells		Function assay		Transactivation of human PPARgamma expressed in human HepG2 cells co-transfected with PPRE3-TK-Luc by luciferase reporter gene assay, EC50=0.05 μM	21450468
HepG2 cells	10 uM	Function assay	24 h	Reduction of glucose consumption in insulin-resistant human HepG2 cells at 10 uM after 24 hrs by glucose oxidase method in presence of 22.2 mM of glucose	23025244
HepG2 cells	10 uM	Function assay	24 h	Reduction of glucose consumption in insulin-resistant human HepG2 cells at 10 uM after 24 hrs by glucose oxidase method in presence of 0.1 uM of insulin	23025244
HepG2 cells		Function assay		Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assay, EC50=0.1 μM	22934537
HepG2 cells		Function assay	20 h	Agonist activity at human GAL4-fused PPARgamma ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivation assay, EC50=0.02 μM	22081932
HepG2 cells		Function assay	20 h	Transactivation of GAL4-fused human PPARgamma ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene assay, EC50=0.039 μM	23171045
HepG2 cells		Function assay		Agonist activity at GAL4-fused PPARgamma (unknown origin) expressed in human HepG2 cells by transactivation assay, EC50=0.01 μM	23502212
HepG2 cells		Function assay		Agonist activity at GAL4-fused PPARgamma M463A mutant (unknown origin) expressed in human HepG2 cells by transactivation assay, EC50=0.002 μM	23502212
HepG2 cells		Function assay	20 hrs	Transactivation of PPAR transfected in human HepG2 cells after 20 hrs by PPAR-luciferase assay, EC50=1.6 μM	25437304
HepG2 cells		Function assay		Agonist activity at human GAL4-PPARgamma ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assay, EC50=0.039 μM	25462281
HepG2 cells		Function assay	20 hrs	Agonist activity at GAL4-DNA binding domain fused human PPARgamma ligand binding domain expressed in human HepG2 cells assessed as receptor transactivation incubated for 20 hrs by luciferase reporter gene assay, EC50=0.04 μM	25497132
HepG2/C3A cells		Function assay		Activation of human PPARgamma ligand binding domain-mediated transcriptional activity in human HepG2/C3A cells co-transfected with fused Gal4-LBD by cotransfection assay, EC50=0.0038 μM	17403688
HT29 cell		Proliferation assay		Antiproliferative activity against human HT29 cell line, EC50=45 μM	16821769
Huh7 cells		Function assay		Functional activity at human PPAR gamma in Huh7 cells by transactivation assay, EC50=0.22 μM	16366601
Huh7 cells		Function assay		Effect on PPAR gamma transactivation activity in Huh7 cells, EC50=0.22 μM	16451087
Huh7 cells		Function assay		Activity at human PPAR gamma in Huh7 cells by transactivation assay, EC50=0.22 μM	17034149
human keratinocytes		Proliferation assay		Antiproliferative activity against human keratinocytes, EC50=8 μM	16821769
human L02 cells		Function assay		Agonist activity at PPARgamma-LBD expressed in human L02 cells co-expressing pGL3-SV40-GAL4 after 24 hrs by luciferase reporter gene based transactivation assay, EC50=0.9 μM	23186307
L6 cells		Function assay	24 hrs	Induction of glucose uptake in rat L6 cells pulsed with C14-deoxy glucose after 24 hrs in presence of insulin, EC50=4.49 μM	23992862
L6 cells		Function assay	16 hrs	Increase in 2-[3H]-deoxyglucose uptake in rat L6 cells after 16 hrs by scintillation counting analysis, EC50=4.8 μM	24813738
MCF7 cells		Function assay	16 h	Agonist activity at human PPARgamma transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assay, EC50=0.087 μM	26226490
MDA-MB-231 cells		Growth inhibition assay	24 hrs	Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay, EC50=5.23 μM	25278236
MG-63 cells		Function assay		Agonist activity at human PPARgamma expressed in MG-63 cells by reporter gene-based transactivation assay, EC50=0.011 μM	22225641
MG-63 cells		Function assay	24 hrs	Modulation of full-length human pSG5-fused PPARgamma expressed in MG-63 cells co-expressing pGV-P2-PPRE after 24 hrs by luciferase reporter gene based transactivation assay, EC50=0.011 μM	22727448
NIH3T3 cells		Function assay		Activity at human PPAR gamma transfected in NIH3T3 cells by luciferase activity assay, EC50=0.32 μM	16854085
NIH3T3 cells		Function assay		Agonist activity at human PPARgamma expressed in NIH3T3 cells by GAL4 transactivation assay, EC50=0.32 μM	17624777
PC3 cells		Cytotoxicity assay	48 hrs	Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT assay, EC50=20.3 μM	24996143
rat L6 cells		Function assay		Effect on fatty acid oxidation in rat L6 cells, EC50=5 μM	17343371
RAW264.7 cells		Function assay		Suppression of LPS/IFN-gamma-stimulated NO production in mouse RAW264.7 cells, EC50=17.5 μM	18809325
THP1 cells	100 uM	Function assay	3 hrs	Transactivation of PPARgamma in human THP1 cells assessed as decrease in LPS-induced MCP1 mRNA expression at 100 uM preincubated for 3 hrs prior to LPS challenge measured after 18 hrs by RT-PCR analysis relative to untreated control	22934537
THP1 cells	100 uM	Function assay	3 hrs	Transactivation of PPARgamma in human THP1 cells assessed as decrease in LPS-induced IL6 mRNA expression at 100 uM preincubated for 3 hrs prior to LPS challenge measured after 18 hrs by RT-PCR analysis relative to untreated control	22934537
U2OS cells		Function assay		Effect on PPARgamma transactivation activity in U2OS cells, EC50=0.03 μM	16300944
U2OS cells		Function assay		Agonist activity at human PPARgamma in U2OS cells by transactivation assay, EC50=0.02 μM	18329751
U2OS cells		Function assay		Agonist activity at human PPARgamma expressed in U2OS cells by luciferase transactivation assay, EC50=0.05 μM	19574056

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4-Methylumbelliferone/羟甲香豆素纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

4-Methylumbelliferone/羟甲香豆素质控信息

4-Methylumbelliferone/羟甲香豆素生物活性

4-Methylumbelliferone/羟甲香豆素细胞研究

4-Methylumbelliferone/羟甲香豆素临床研究

4-Methylumbelliferone/羟甲香豆素参考文献

4-Methylumbelliferone/羟甲香豆素实验方案

4-Methylumbelliferone/羟甲香豆素技术信息

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4-Methylumbelliferone/羟甲香豆素 参考文献

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4-Methylumbelliferone/羟甲香豆素质控信息

4-Methylumbelliferone/羟甲香豆素生物活性

4-Methylumbelliferone/羟甲香豆素细胞研究

4-Methylumbelliferone/羟甲香豆素临床研究

4-Methylumbelliferone/羟甲香豆素参考文献

4-Methylumbelliferone/羟甲香豆素实验方案

4-Methylumbelliferone/羟甲香豆素技术信息