There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
10074-G5 is effective in hindering the proliferation of Daudi Burkitt's lymphoma cells and in interfering with the dimerization of c-Myc/Max. It exhibits IC50 values of 15.6 μM for Daudi cells and 13.5 μM for HL-60 cells[1]. 10074-G5 interacts with the Myc peptide Myc353-437, exhibiting a Kd value of 2.8 μM within the Arg363-Ile381 region. It attaches within a pocket formed by a bend (Asp379-Ile381) at the N-terminal end of an induced helical segment (Leu370–Arg378)[2].
作用机制
10074-G5 can disrupt the dimeric complex formed between its basic helix-loop-helix leucine zipper (bHLHZip) domain and a similar domain on its dimerization partner, Max. Similar to 10058-F4, 10074-G5 binds to c-Myc, but a distinct region[1].
[1][2][3][4][5]
10074-G5 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
Daudi cells
Cytotoxicity assay
3 to 5 days
Cytotoxicity against human Daudi cells assessed as growth inhibition after 3 to 5 days by MTT assay, IC50=10 Μm
23177256
HL60 cells
Cytotoxicity assay
3 to 5 days
Cytotoxicity against human HL60 cells assessed as growth inhibition after 3 to 5 days by MTT assay, IC50=30 μM
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