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/ Calcium Channel / (S)-(-)-Bay-K-8644

(S)-(-)-Bay-K-8644 {[allProObj[0].p_purity_real_show]}

货号：A273444

Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM).

(S)-(-)-Bay-K-8644 化学结构 CAS号：98625-26-4
(S)-(-)-Bay-K-8644 化学结构
CAS号：98625-26-4
(S)-(-)-Bay-K-8644 3D分子结构
CAS号：98625-26-4
(S)-(-)-Bay-K-8644 化学结构 CAS号：98625-26-4
(S)-(-)-Bay-K-8644 3D分子结构 CAS号：98625-26-4
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(S)-(-)-Bay-K-8644 纯度/质量文件 产品仅供科研

货号：A273444 标准纯度： {[allProObj[0].p_purity_real_show]}
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(S)-(-)-Bay-K-8644 生物活性

描述 (S) -(-)-Bay K 8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on IBa in gastric myocytes of the guinea pig antrum[3]. The channel activity was enhanced by 3-30 microM S(-)Bay K 8644, an agonist of L-type Ca2+ channels[4]. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC50=14 nM). (S)-Bay K 8644 (100 nM) increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulation by 1 microM FPL 64176[5]. S-(-)-Bay K 8644 failed to produce characteristically large increases in current when cells were held at -40 mV and Ca2+ was used as the charge carrier, although high-affinity binding and the effects of the antagonist isomer, R-(+)-Bay K 8644, were intact. The pharmacology of S-(-)-Bay K 8644 in stem cell-derived cardiomyocytes varies by cell type, is unusually dependent on holding potential and charge carrier, and is different from that observed in primary human heart cells[6].

(S)-(-)-Bay-K-8644 参考文献

[1]Mironov SL, Richter DW. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1):75-87.

[2]Rampe D, Dage RC. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602.

[3]Zhu HL, Teramoto N. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15

[4]Mironov SL, Richter DW. L-type Ca2+ channels in inspiratory neurones of mice and their modulation by hypoxia. J Physiol. 1998 Oct 1;512 ( Pt 1)(Pt 1):75-87

[5]Rampe D, Dage RC. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. Mol Pharmacol. 1992 Apr;41(4):599-602

[6]Ji J, Kang J, Rampe D. L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier. Assay Drug Dev Technol. 2014 Aug;12(6):352-60

(S)-(-)-Bay-K-8644 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.07mL

5.61mL

2.81mL

(S)-(-)-Bay-K-8644 技术信息

CAS号98625-26-4
分子式C16H15F3N2O4
分子量 356.3
SMILES Code CC1=C([N+]([O-])=O)[C@@H](C2=C(C(F)(F)F)C=CC=C2)C(C(OC)=O)=C(C)N1
MDL No. MFCD00153769
别名
运输蓝冰
InChI Key ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
Pubchem ID 6603728
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, 2-8°C
溶解方案 请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: (S)-(-)-Bay-K-8644 | 98625-26-4 | Calcium Channel | Ca2+ channels | Calcium Channel Agonist | Membrane Transporter/Ion Channel | Neuronal Signaling | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | (S)-(-)-Bay-K-8644 纯度/质量文件 | (S)-(-)-Bay-K-8644 亚型比较 | (S)-(-)-Bay-K-8644 生物活性 | (S)-(-)-Bay-K-8644 参考文献 | (S)-(-)-Bay-K-8644 实验方案 | (S)-(-)-Bay-K-8644 技术信息

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