(3R,4S)-Tofacitinib | JAK Inhibitor | AmBeed-信号通路专用抑制剂

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(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 {[allProObj[0].p_purity_real_show]}

货号：A629449

(3R,4S)-Tofacitinib is an isomer of tofacitinib, an inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

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Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼化学结构
CAS号：1092578-46-5

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 3D分子结构
CAS号：1092578-46-5

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(3R,4S)-Tofacitinib/(3R,4S)-托法替尼纯度/质量文件产品仅供科研

货号：A629449 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: 更多 >

JAK 亚型比较

产品名称	JAK1 ↓ ↑	JAK2 ↓ ↑	JAK3 ↓ ↑	Tyk2 ↓ ↑	其他靶点	纯度
Decernotinib	+++ JAK1, IC50: 11 nM JAK1, Ki: 11 nM	+++ JAK2, Ki: 13 nM	++++ JAK3, Ki: 2.5 nM	+++ TYK2, Ki: 13 nM		99%+
ZM39923 HCl	+ JAK1, pIC50: 4.4		+ JAK3, pIC50: 7.1		EGFR	97%
Cerdulatinib	+++ JAK1, IC50: 12 nM	+++ JAK2, IC50: 6 nM	+++ JAK3, IC50: 8 nM	++++ TYK2, IC50: 0.5 nM		99%+
Momelotinib	+++ JAK1, IC50: 11 nM	++ JAK2, IC50: 18 nM	+ JAK3, IC50: 155 nM			99%+
XL019	+ JAK1, IC50: 134.3 nM	++++ JAK2, IC50: 2.2 nM	+ JAK3, IC50: 214.2 nM		FLT3	99%+
Ruxolitinib	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM				98%
Tofacitinib	+ JAK1, IC50: 112 nM	++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			98%
Ruxolitinib (S enantiomer)	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM		++ TYK2, IC50: 19 nM		98%
Filgotinib	+++ JAK1, IC50: 10 nM	++ JAK2, IC50: 28 nM	+ JAK3, IC50: 810 nM	+ TYK2, IC50: 116 nM		99%
Baricitinib	+++ JAK1, IC50: 5.9 nM	+++ JAK2, IC50: 5.7 nM		++ TYK2, IC50: 53 nM		99%
Gandotinib	++ JAK1, IC50: 19.8 nM	++++ JAK2, IC50: 0.288 nM JAK2 (V617F), Ki: 0.245 nM	++ JAK3, IC50: 48.0 nM	++ TYK2, IC50: 44 nM	FLT3	99%+
Oclacitinib maleate	+++ JAK1, IC50: 10nM	++ JAK2, IC50: 18nM	+ JAK3, IC50: 99nM	+ TYK2, IC50: 84nM		98+%
NVP-BSK805 2HCl	++ JAK1, IC50: 31.63 nM	++++ JAK2, IC50: ~0.5 nM	++ JAK3, IC50: 18.68 nM	+++ TYK2, IC50: 10.76 nM		95%
Peficitinib		✔				98%
Go6976		✔			FLT3	99%+
AZD-1480		++++ JAK2, IC50: 0.26 nM				99%+
Fedratinib		+++ JAK2, IC50: 3 nM JAK2 (V617F), IC50: 3 nM			FLT3,RET	99%+
WP1066		+ JAK2, IC50: 2.3 μM				98%
Curcumol		✔				98%
AZ960		++++ JAK2, IC50: <3 nM JAK2, Ki: 0.45 nM				97%
GLPG0634 analog		✔				99%+
CEP-33779		++++ JAK2, IC50: 1.8 nM				99%+
FLLL32		+ JAK2, IC50: <5 μM				99%+
WHI-P154			+ JAK3, IC50: 1.8 μM		EGFR,VEGFR,Src	98%
BMS-911543		++++ JAK2, IC50: 1.1 nM	+ JAK3, IC50: 75 nM	++ TYK2, IC50: 66 nM		95%
TG101209		+++ JAK2, IC50: 6 nM	+ JAK3, IC50: 169 nM		FLT3,RET	99%+
AT9283		++++ JAK2, IC50: 1.2 nM	++++ JAK3, IC50: 1.1 nM			99%+
Pacritinib		++ JAK2, IC50: 23 nM JAK2 (V617F), IC50: 19 nM	+ JAK3, IC50: 520 nM	++ TYK2, IC50: 50 nM	FLT3	97%
Tofacitinib citrate		++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			99%
FM-381			++++ JAK3, IC50: 127 pM			98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼生物活性

描述	(3R,4S)-Tofacitinib is an isomer of tofacitinib, an inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼参考文献

[1]Changelian PS, Flanagan ME, et al, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science, 2003, 302(5646), 875-878.

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.20mL

0.64mL

0.32mL

16.01mL

3.20mL

1.60mL

32.01mL

6.40mL

3.20mL

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼技术信息

CAS号	1092578-46-5
分子式	C₁₆H₂₀N₆O
分子量	312.37
SMILES Code	N#CCC(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@@H](C)CC1)=O
MDL No.	MFCD23160057

别名
运输	蓝冰
InChI Key	UJLAWZDWDVHWOW-AAEUAGOBSA-N
Pubchem ID	25180101

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 {[allProObj[0].p_purity_real_show]}

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼质控信息

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼生物活性

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼参考文献

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼实验方案

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(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 {[allProObj[0].p_purity_real_show]}

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 质控信息

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 生物活性

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 参考文献

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼 实验方案

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摩尔计算器

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总药量计算器

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(3R,4S)-Tofacitinib/(3R,4S)-托法替尼纯度/质量文件产品仅供科研

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼质控信息

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼生物活性

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼参考文献

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼实验方案

(3R,4S)-Tofacitinib/(3R,4S)-托法替尼技术信息