(±)-Praeruptorin A | 白花前胡甲素 | Praeruptorin A | Calcium Channel Inhibitor

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(±)-Praeruptorin A/(±)-白花前胡甲素 {[allProObj[0].p_purity_real_show]}

货号：A644340 同义名： 白花前胡甲素 / Praeruptorin A

(±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.

(±)-Praeruptorin A/(±)-白花前胡甲素化学结构
CAS号：73069-25-7

(±)-Praeruptorin A/(±)-白花前胡甲素 3D分子结构
CAS号：73069-25-7

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(±)-Praeruptorin A/(±)-白花前胡甲素纯度/质量文件产品仅供科研

货号：A644340 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: 更多 >

Calcium Channel 亚型比较

产品名称	Ca2+ channel-like protein ↓ ↑	Calcium Channel ↓ ↑	Cav 2.2 ↓ ↑	其他靶点	纯度
CDC25B-IN-2	✔			Akt	99%+
Clevidipine		✔			97%
Verapamil HCl		✔			99%
Amlodipine		✔			99%
Amlodipine maleate		✔			98%
(+)-cis-Diltiazem HCl		✔			99%
Zegocractin		++ Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM			99%+
Tanshinone IIA sulfonate sodium		✔			98%
Ulixacaltamide		++ hCaV3.1, IC50: 50 nM hCaV3.2, IC50: 110 nM			99%+
Dronedarone HCl		✔			95%
Nitrendipine		+ Calcium channel, IC50: 95 nM			98%
Efonidipine HCl monoethanolate		✔			98%
Cinnarizine		✔			98%
SEA0400		++ NCX, IC50: 33 nM		ROS,ERK,p38 MAPK	99%+
Fasudil HCl		✔		PKA,Rho	98%
ML-9		✔		Akt,MLCK	99%+
Flunarizine 2HCl		+ Calcium channel, Ki: 68 nM			95%
Lomerizine 2HCl		✔			98%
Efonidipine		✔			98%
Levamlodipine		✔			98%
Nisoldipine		++ L-type Cav1.2, IC50: 10 nM			97%
Isradipine		✔			98%
Lacidipine		✔			98%
Lercanidipine		✔			99%
Loureirin B		✔		Potassium Channel	99%+
Tetracaine HCl		✔			98%
Manidipine		+++ Calcium channel, IC50: 2.6 nM			99%
Manidipine Dihydrochlorid		+++ Calcium channel, IC50: 2.6 nM			98%
Nicardipine		✔			99%
Wilforgine		✔			98+%
Econazole		✔			99%+
Ginsenoside Rd		✔		NF-κB	98%
Fendiline HCl		✔			98+%
Mesaconitine		✔			98%
Tetrandrine		✔			95%
Nifedipine		✔			95%
Nilvadipine		++++ Calcium channel, IC50: 0.03 nM			98%
Barnidipine		++++ [³H]nitrendipine, Ki: 0.21 nM			95+%
Azelnidipine		✔			97%
Levetiracetam		✔			98%
Nimodipine		✔			95%
Benidipine HCl		✔			98%
Pinaverium bromide		✔			98%
Pranidipine		✔			99%
NP118809		+ N-type Ca2+ channel, IC50: 0.11 μM L-type calcium channel, IC50: 12.2 μM			98%
Amlodipine Besylate		+++ Calcium channel, IC50: 1.9 nM			97%
Cilnidipine		✔			99%
Cinepazide Maleate		✔			99% (HPLC)
Terfenadine		✔			98%
YM-58483		✔			99%+
Ranolazine		✔			98%
Praeruptorin A		✔		p38 MAPK,Akt	98%
Ranolazine 2HCl		✔			98%
Felodipine		++++ L-type calcium channel, IC50: 0.15 nM			98%
PD173212		+++ N-type Ca2+ channel, IC50: 36 nM			98%
Levamlodipine besylate		✔			97%
Carboxyamidotriazole Orotate		✔			98%
IGS-1.76		✔			98+%
WH-4-023		++++ Cav 2.2, IC50: 0.001 μM	++++ Cav 2.2, IC50: 0.001 μM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(±)-Praeruptorin A/(±)-白花前胡甲素生物活性

描述

(±)-Praeruptorin A/(±)-白花前胡甲素参考文献

[1]Yeon JT, Choi SW, et al. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin. J Nat Prod. 2015 Apr 24;78(4):776-82.

[2]Yeon JT, Kim KJ, et al. Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. PLoS One. 2014 Feb 21;9(2):e88974.

(±)-Praeruptorin A/(±)-白花前胡甲素实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.88mL

5.18mL

2.59mL

(±)-Praeruptorin A/(±)-白花前胡甲素技术信息

CAS号	73069-25-7
分子式	C₂₁H₂₂O₇
分子量	386.4
SMILES Code	C/C=C(C)\C(O[C@H]1C(C)(C)OC2=C(C3=C(C=CC(O3)=O)C=C2)[C@H]1OC(C)=O)=O
MDL No.	N/A

别名	白花前胡甲素 ;Praeruptorin A
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

(±)-Praeruptorin A/(±)-白花前胡甲素 {[allProObj[0].p_purity_real_show]}

(±)-Praeruptorin A/(±)-白花前胡甲素纯度/质量文件产品仅供科研

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(±)-Praeruptorin A/(±)-白花前胡甲素生物活性

(±)-Praeruptorin A/(±)-白花前胡甲素参考文献

(±)-Praeruptorin A/(±)-白花前胡甲素实验方案

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(±)-Praeruptorin A/(±)-白花前胡甲素 实验方案

(±)-Praeruptorin A/(±)-白花前胡甲素 技术信息

最近浏览的产品

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摩尔计算器

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总药量计算器

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(±)-Praeruptorin A/(±)-白花前胡甲素纯度/质量文件产品仅供科研

(±)-Praeruptorin A/(±)-白花前胡甲素质控信息

(±)-Praeruptorin A/(±)-白花前胡甲素生物活性

(±)-Praeruptorin A/(±)-白花前胡甲素参考文献

(±)-Praeruptorin A/(±)-白花前胡甲素实验方案

(±)-Praeruptorin A/(±)-白花前胡甲素技术信息