同义名 :	NSC 93754
	CAS号 :	77-60-1
	货号 :	A993709
	分子式 :	C27H44O3
	纯度 :	98%
	分子量 :	416.64
	MDL号 :	MFCD00067287
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Tigogenin, a natural product isolated and purified from the herbs of Agave sisalana Perrine, induces apoptosis, associated with overexpression of COX-2 correlated with overproduction of endogenous PGE2, and may modulate differentiation of BMSCs to cause a lineage shift away from the adipocytes and toward the osteoblasts, which is at least mediated by inhibition of PPARgamma and via p38 MAPK pathway.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.40mL 0.48mL 0.24mL	12.00mL 2.40mL 1.20mL	24.00mL 4.80mL 2.40mL

参考文献
[1]Gu G, An L, et al. Efficient one-pot synthesis of tigogenin saponins and their antitumor activities. Carbohydr Res. 2014 Jan 13;383:21-6. [2]Zhou H, Yang X, et al. Tigogenin inhibits adipocytic differentiation and induces osteoblastic differentiation in mouse bone marrow stromal cells. Mol Cell Endocrinol. 2007 May 30;270(1-2):17-22.