CP 376395

产品说明书

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Chemical Structure| 175140-00-8 同义名 : CP 316,311
CAS号 : 175140-00-8
货号 : A984984
分子式 : C21H30N2O
纯度 : 99%+
分子量 : 326.48
MDL号 : MFCD14584860
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CP 376395 is a potent, selective, and centrally penetrable antagonist of the Corticotropin-releasing factor 1 (CRF1) receptor[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.31mL

3.06mL

1.53mL

30.63mL

6.13mL

3.06mL
参考文献

[1]Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.

[2]Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70.