同义名 :	-
	CAS号 :	88929-35-5
	货号 :	A982800
	分子式 :	C6H10N2O3
	纯度 :	98%
	分子量 :	158.16
	MDL号 :	MFCD00242951
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Oxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic drug to treat cognitive impairments[3]. ORC (Oxiracetam) suppressed the activation of BV2 cells, decreased the production of Aβ-induced inflammatory molecules and NO in BV2 cells, and protected HT22 cells against indirect toxicity mediated by Aβ-treated BV2 cell-conditioned medium[4]. ORC (100 mg/kg or 200 mg/kg) treatment significantly alleviated learning and memory deficits and neuronal damage in rats with VaD (vascular dementia)[5]. Moreover, oxiracetam at a dose of 800 mg/kg enhanced metabolism impaired by diaschisis in the caudal areas of the contralateral cortex[6]. NGF (nerve growth factor) in combination with oxiracetam is significantly effective in treating hypertensive cerebral hemorrhage as it can apparently recover neurologic impairment and limbs muscle force[7].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	6.32mL 1.26mL 0.63mL	31.61mL 6.32mL 3.16mL	63.23mL 12.65mL 6.32mL

参考文献

[1]Yao XL, Yao ZH, et al. Oxiracetam can improve cognitive impairment after chronic cerebral hypoperfusion in rats. Psychiatry Res. 2016 Dec 30;246:284-292. [2]Li JW, Yang DJ, et al. [Protective effect of oxiracetam on traumatic brain injury in rats] . Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Jul;29(4):298-300. [3]Hu S, Shi J, Xiong W, Li W, Fang L, Feng H. Oxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude. Brain Behav. 2017 Aug 23;7(10):e00762 [4]Zhang H, Jia L, Jia J. Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer's Disease. Front Neurol. 2020 Jul 17;11:623 [5]Xu J, Qi Q, Lv P, Dong Y, Jiang X, Liu Z. Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway. Braz J Med Biol Res. 2019 Nov 7;52(11):e8371 [6]Hokonohara T, Sako K, Shinoda Y, Tomabechi M, Yonemasu Y. The effects of oxiracetam (CT-848) on local cerebral glucose utilization after focal cerebral ischemia in rats. Jpn J Pharmacol. 1992 Feb;58(2):127-35 [7]Sun Y, Xu B, Zhang Q. Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage. Pak J Med Sci. 2018 Jan-Feb;34(1):73-77