A-674563 HCl

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Chemical Structure| 2070009-66-2 同义名 : A-674563 hydrochloride
CAS号 : 2070009-66-2
货号 : A976883
分子式 : C22H23ClN4O
纯度 : 99%
分子量 : 394.9
MDL号 : MFCD18711680
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • Akt1

    Akt1, Ki:11 nM

  • Akt1

    Akt1, Ki:11 nM

  • CDK2

    CDK2, Ki:46 nM

  • PKA

    PKA, Ki:16 nM

  • PKA

    PKA, Ki:16 nM
描述 A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.53mL

0.51mL

0.25mL

12.66mL

2.53mL

1.27mL

25.32mL

5.06mL

2.53mL
参考文献

[1]Zhu QS, Ren W, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res. 2008 Apr 15;68(8):2895-903.

[2]Luo Y, Shoemaker AR, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86.