RSVA405
产品说明书
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同义名 : | - |
| CAS号 : | 140405-36-3 | |
| 货号 : | A975040 | |
| 分子式 : | C17H20N4O2 | |
| 纯度 : | 95% | |
| 分子量 : | 312.37 | |
| MDL号 : | MFCD00542031 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | RSVA405 is a potent orally active activator of AMPK with an EC50 value of 1 μM.RSVA405 promotes CaMKKβ-dependent activation of AMPK, inhibits mTOR, and facilitates autophagy to increase Aβ degradation.RSVA405 has anti-inflammatory effects through inhibition of STAT3.RSVA405 has been used in the study of obesity[1][2][3][4]. In the concentration range of 0.2-2 μM for 24 hours, RSVA405 inhibited adipocyte differentiation and significantly suppressed the expression of PPARγ, FAS and aP2 in 3T3-L1 cells[2].In the concentration range of 1-3 μM for 16 hours, RSVA405 inhibited LPS-induced STAT3 activity, intracellular signalling and cytokine responses in activated RAW 264.7 macrophages[3] .In the concentration range of 1-3 μM, acting for 24 hours, RSVA405 inhibited mTOR, induced autophagy, promoted lysosomal degradation of Aβ, and had an EC50 value of 1 μM in APP-HEK293 cells[4] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.20mL 0.64mL 0.32mL |
16.01mL 3.20mL 1.60mL |
32.01mL 6.40mL 3.20mL |
