VER-82576

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Chemical Structure| 847559-80-2 同义名 : NVP-BEP800
CAS号 : 847559-80-2
货号 : A969983
分子式 : C21H23Cl2N5O2S
纯度 : 99%+
分子量 : 480.41
MDL号 : MFCD18251568
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NVP-BEP800 is a fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits> 70-fold selectivity against Hsp90 family members Grp94 and Trap-1.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.41mL

2.08mL

1.04mL

20.82mL

4.16mL

2.08mL
参考文献

[1]Massey AJ, Schoepfer J, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9(4):906-19.

[2]Stuhmer T, Chatterjee M, et al. Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800. Br J Haematol. 2009 Nov;147(3):319-27.