MMPEP

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Chemical Structure| 823198-78-3 同义名 : -
CAS号 : 823198-78-3
货号 : A963537
分子式 : C15H14ClNO
纯度 : 98%
分子量 : 259.73
MDL号 : MFCD19440696
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 MMPEP is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM and a mGlu4 receptor positive allosteric modulator.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.85mL

0.77mL

0.39mL

19.25mL

3.85mL

1.93mL

38.50mL

7.70mL

3.85mL
参考文献

[1]Chau P, Soderpalm B, et al. The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addict Biol. 2011 Oct;16(4):591-9.

[2]Gasparini F, Lingenhohl K, et al. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503.