URB937

产品说明书

Print
Chemical Structure| 1357160-72-5 同义名 : -
CAS号 : 1357160-72-5
货号 : A950546
分子式 : C20H22N2O4
纯度 : 99%+
分子量 : 354.4
MDL号 : MFCD22987960
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 URB937 is a peripherally restricted FAAH inhibitor with oral activity and an IC50 value of 26.8 nM. URB937 does not affect FAAH activity in the brain (does not penetrate the blood-brain barrier)[1].URB937 is actively excreted from the CNS by the ATP-binding cassette (ABC) membrane transporter Abcg2[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Jason R Clapper, et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct;13(10):1265-70.