Takinib

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Chemical Structure| 1111556-37-6 同义名 : EDHS-206
CAS号 : 1111556-37-6
货号 : A949172
分子式 : C18H18N4O2
纯度 : 98%
分子量 : 322.36
MDL号 : MFCD11822633
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Takinib is a selective TAK1 inhibitor with IC50 of 9.5 nM, it can induce apoptosis in a TNF-α-dependent manner in rheumatoid arthritis (RA) and breast cancer models.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.10mL

0.62mL

0.31mL

15.51mL

3.10mL

1.55mL

31.02mL

6.20mL

3.10mL
参考文献

[1]Totzke J, Gurbani D, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. Cell Chem Biol. 2017;24(8):1029-1039.e7.