TLR4-IN-C34

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Chemical Structure| 40592-88-9 同义名 : TLR4-C34; C34; Toll-Like Receptor 4-C34; TLR4-C34-IN
CAS号 : 40592-88-9
货号 : A932319
分子式 : C17H27NO9
纯度 : 98%
分子量 : 389.4
MDL号 : MFCD28053519
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 The innate immune receptor toll-like receptor 4 (TLR4) is a pattern recognition receptor expressed in both hematopoietic and non-hematopoietic cells. C34 is a 2-acetamidopyranoside that inhibits TLR4 in IEC-6 enterocytes and RAW264.7 macrophages in vitro at a dosage of 10μM. Pretreatment with 1mg/kg C34 30 minutes before LPS (3mg/kg) injection significantly reduced luciferase activity in mice. In a mouse model of experimental necrotizing enterocolitis (NEC), oral gavage of C34 (1mg/kg/day) for 4 days attenuated the severity of NEC as demonstrate by marked preservation of the intestinal mucosa, downregulation of pro-inflammatory iNOS expression, and reduced NEC severity score. C34 at 10μM inhibited TLR4 signaling ex vivo in human tissues isolated from infants with NEC[2].
作用机制 C34 is an inhibitor of TLR4 that docks into the hydrophobic internal pocket of the TLR4 co-receptor MD-2[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.84mL

2.57mL

1.28mL

25.68mL

5.14mL

2.57mL
参考文献

[1]Neal MD, Jia H, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779.

[2]Neal MD, Jia H, Eyer B, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779.