H-151
产品说明书
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同义名 : | - |
| CAS号 : | 941987-60-6 | |
| 货号 : | A923731 | |
| 分子式 : | C17H17N3O | |
| 纯度 : | 99%+ | |
| 分子量 : | 279.34 | |
| MDL号 : | MFCD08026581 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | H-151 is a potent and selective STING antagonist. It dose-dependently abrogated IFNβ luciferase reporter at concentration ranging in 0.02-2μM in HEK293T cells. It reduced TBK1 phosphorylation (0.5μM, for 2h) in THP-1 cells and suppression of hsSTING palmitoylation (1μM, for 3h) without affecting respective controls. Pre-treatment of H-151 markedly reduced systemic cytokine responses in CMA (STING agonist)-treated mice[2]. | ||
| 作用机制 | H-151 can bind covalently with Cys91 of hsSTING.[2] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.58mL 0.72mL 0.36mL |
17.90mL 3.58mL 1.79mL |
35.80mL 7.16mL 3.58mL |
| 参考文献 |
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