Gemcitabine elaidate

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Chemical Structure| 210829-30-4 同义名 : 吉西他滨反油酸酯 ;CO-101; Cp-4126; Gemcitabine 5'-elaidate
CAS号 : 210829-30-4
货号 : A922777
分子式 : C27H43F2N3O5
纯度 : 96%
分子量 : 527.64
MDL号 : MFCD15145214
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Gemcitabine elaidate (CP-4126) is a lipophilic prodrug of Gemcitabine. It undergoes conversion to Gemcitabine by esterases prior to phosphorylation. Gemcitabine elaidate demonstrates anti-tumor activity [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.95mL

3.79mL

1.90mL
参考文献

[1]Bergman AM, et, al. Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2011 Jun;29(3):456-66.

[2]Adema AD, et, al. Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36(1):285-94.