L-798106

产品说明书

Print
Chemical Structure| 244101-02-8 同义名 : CM9; GW671021
CAS号 : 244101-02-8
货号 : A912792
分子式 : C27H22BrNO4S
纯度 : 99%
分子量 : 536.44
MDL号 : MFCD08272644
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 L-798106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2, respectively), and it can attenuate sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.32mL

1.86mL

0.93mL

18.64mL

3.73mL

1.86mL
参考文献

[1]Li C, Liu X, et al. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Mol Cancer Res. 2017 Jul 14. pii: molcanres.0077.2017.

[2]Bassil AK, Borman RA, et al. Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon. Br J Pharmacol. 2008 May;154(1):126-35.