同义名 :	G10
	CAS号 :	702662-50-8
	货号 :	A910101
	分子式 :	C21H16ClFN2O3S
	纯度 :	99%+
	分子量 :	430.88
	MDL号 :	MFCD04062826
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

STING is a pattern recognition receptor of cyclic dinucleotides and an innate immune adaptor protein. STING agonist-1 is a human-specific STING agonist with antiviral activity. It inhibited replication of Chikungunya Virus and Venezuelan Equine Encephalitis Virus with IC90 values 8.01μM of 24.57μM, respectively. Exposing human fibroblasts to STING agonist-1 (100μM) led to transcription of cellular genes triggered by IRF3/IFN-dependent signaling, but not NF-κB-dependent signaling. STING agonist-1 at a concentration of 100μM also induced IRF3 phosphorylation and elicited anti-alphaviral activity in cells lacking IPS1. In human peripheral blood mononuclear cells, treatment with STING agonist-1 (25–100μM) for 8 hours induced innate antiviral mRNA expression, including IFIT1, IFIT2, IFNβ, ISG15, OAS, and Viperin[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.32mL 0.46mL 0.23mL	11.60mL 2.32mL 1.16mL	23.21mL 4.64mL 2.32mL

参考文献
[1]Sali TM, Pryke KM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. [2]Sali TM, Pryke KM, Abraham J, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015;11(12):e1005324.