RGB-286638 free base

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Chemical Structure| 784210-88-4 同义名 : RGB-286638
CAS号 : 784210-88-4
货号 : A908306
分子式 : C29H35N7O4
纯度 : 98%
分子量 : 545.63
MDL号 : MFCD18633230
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 RGB-286638 free base is a CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively and less potent against cyclin H-CDK7 and cyclin D3-CDK6.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.16mL

1.83mL

0.92mL

18.33mL

3.67mL

1.83mL
参考文献

[1]Cirstea D, Hideshima T, et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75.