Gadolinium chloride

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Chemical Structure| 10138-52-0 同义名 : 氯化钆 ;GdCl3
CAS号 : 10138-52-0
货号 : A907506
分子式 : Cl3Gd
纯度 : 99.95% (REO)
分子量 : 263.61
MDL号 : MFCD00011024
存储条件:

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Gadolinium chloride is a specific CaSR agonist.Gadolinium chloride is used in cardiovascular disease research to promote apoptosis in cardiomyocytes, increase ERK1/2 phosphorylation and activate caspase-3. Gadolinium chloride at a concentration of 30 μM for 15 minutes resulted in an increase in Bax expression and caspase-3 activation and a decrease in Bcl-2 expression in H9c2 cells induced by CsA[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.79mL

0.76mL

0.38mL

18.97mL

3.79mL

1.90mL

37.93mL

7.59mL

3.79mL

参考文献

[1]References are publications that support the biological activity of the product. Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183 Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333 Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474 Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548 If you know of a relevant reference for Gadolinium chloride, please let us know.