YM-750
产品说明书
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同义名 : | - |
| CAS号 : | 138046-43-2 | |
| 货号 : | A901198 | |
| 分子式 : | C31H36N2O | |
| 纯度 : | 99% | |
| 分子量 : | 452.63 | |
| MDL号 : | MFCD00905424 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | YM-750 is a potent ACAT inhibitor with an IC50 value of 0.18 μM. ACAT catalyses the formation of cholesterol esters from cholesterol and long-chain fatty acyl coenzyme A[1][2].In the absence of Cu2+ and in the presence of acLDL, esterified cholesterol accumulates in foam cells for up to 24 hours, and YM-750 inhibits this accumulation[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00794209 | Healthy | Phase 1 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.21mL 0.44mL 0.22mL |
11.05mL 2.21mL 1.10mL |
22.09mL 4.42mL 2.21mL |
