Plicamycin

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Chemical Structure| 18378-89-7 同义名 : Mithramycin A; A 2371; mithramycin; PA 144; NSC 24559; Aureolic Acid; Antibiotic LA 7017
CAS号 : 18378-89-7
货号 : A899765
分子式 : C52H76O24
纯度 : 98+%
分子量 : 1085.15
MDL号 : MFCD00135618
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.92mL

0.18mL

0.09mL

4.61mL

0.92mL

0.46mL

9.22mL

1.84mL

0.92mL
参考文献

[1]Wei C, Zhang W, et al. Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease. Neurochem Res. 2016 Aug;41(8):1924-38.

[2]Saha S, Mukherjee S, et al. Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin. Transl Res. 2015 May;165(5):558-77.