Quipazine dimaleate
产品说明书
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同义名 : | - |
| CAS号 : | 150323-78-7 | |
| 货号 : | A899321 | |
| 分子式 : | C21H23N3O8 | |
| 纯度 : | 99%+ | |
| 分子量 : | 445.42 | |
| MDL号 : | MFCD00082322 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Quipazine dimaleate functions as a 5-HT agonist, evidenced by its Ki of 1.4 nM in displacing [3H]GR65630 from 5-HT3R in rats. It also exhibits antiviral properties against SARS-CoV-2, with an EC50 of 31.64 μM. In peripheral models, quipazine dimaleate acts as an antagonist to 5-HT3R. Its utility extends to the research of neurological diseases[1][2][3][4]. Quipazine dimaleate exhibits antagonistic effects on the rat vagus nerve, with pIC50 values of 6.1 for 5-HT2, 6.49 for 5-HT1, and 6.17 for the inhibition of 5-HT release[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.22mL |
11.23mL 2.25mL 1.12mL |
22.45mL 4.49mL 2.25mL |
