Chloropyramine HCl
产品说明书
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同义名 : | 盐酸氯吡胺 ;Chloropyramine hydrochloride; Halopyramine hydrochloride; Alergosan, Allergan S hydrochloride, Chloropyramine hydrochloride, Chloropyramine HCl, Chloropyribenzamine hydrochloride, Halopyramine hydrochloride, Nilfan, Sinopen, Suprastin |
| CAS号 : | 6170-42-9 | |
| 货号 : | A897986 | |
| 分子式 : | C16H21Cl2N3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 326.26 | |
| MDL号 : | MFCD00079009 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BT474 cells demonstrate a high sensitivity to Chloropyramine hydrochloride (compound 1), with a 1 µM concentration leading to a 40% reduction in cell viability after 48 hours. At the same 1 µM concentration, the viability of MCF7-pcDNA3 cells remains significantly higher compared to MCF7-VEGFR-3 cells (P<0.01), and at a 10 µM concentration, the viability difference doubles (P<0.001). Additionally, a concentration-dependent decrease in cell proliferation is observed in BT474 cells treated with Chloropyramine hydrochloride. A continued 48-hour treatment at higher doses leads to apoptosis in breast cancer cells overexpressing VEGFR-3, with a 10 µM dose inducing apoptosis in over 60% of these cells. In comparative treatments, MCF7-pcDNA3 and MCF7-VEGFR-3 cells treated with 10 µM Chloropyramine hydrochloride for 48 hours show a fourfold increase in apoptotic cell death in the VEGFR-3 overexpressed line (18% vs. 76% respectively)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.07mL 0.61mL 0.31mL |
15.33mL 3.07mL 1.53mL |
30.65mL 6.13mL 3.07mL |
| 参考文献 |
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