ASP7663

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Chemical Structure| 1190217-35-6 同义名 : -
CAS号 : 1190217-35-6
货号 : A897050
分子式 : C14H14FNO3
纯度 : 99%
分子量 : 263.26
MDL号 : MFCD29079014
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.80mL

0.76mL

0.38mL

18.99mL

3.80mL

1.90mL

37.99mL

7.60mL

3.80mL
参考文献

[1]Lu Y, Piplani H, et al. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016 Dec;125(6):1171-1180.

[2]Kojima R, Nozawa K, et al. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur J Pharmacol. 2014 Jan 15;723:288-93.