Eeyarestatin I
产品说明书
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同义名 : | Eeyarestatin 1 |
| CAS号 : | 412960-54-4 | |
| 货号 : | A893133 | |
| 分子式 : | C27H25Cl2N7O7 | |
| 纯度 : | 99%+ | |
| 分子量 : | 630.44 | |
| MDL号 : | MFCD00319108 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Eeyarestatin I is a potent inhibitor of endoplasmic reticulum-associated protein degradation (ERAD) and a potent inhibitor of protein translocation. Eeyarestatin I inhibits the Sec61 translocon. Eeyarestatin I targets the process of p97-associated deubiquitination (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes with a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the pro-apoptotic protein NOXA and has anticancer effects[1][2][3][4][5].Acting in the 2.5-40 μM concentration range for 48 hours, Eeyarestatin I increases endoplasmic reticulum (ER) stress markers, including Bip and CHOP as low as 20 μM, and can lead to cell death in A549 and H358 cells in a dose-dependent manner and ubiquitylation of key proteins, including PERK and IRE1α[1].Eeyarestatin I prevents the transfer of nascent proteins from the membrane-targeting complex to the ER transporter machinery, most likely by inactivating the Sec61 complex[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.59mL 0.32mL 0.16mL |
7.93mL 1.59mL 0.79mL |
15.86mL 3.17mL 1.59mL |
