Derenofylline
产品说明书
 |
同义名 : | Slv 320 |
| CAS号 : | 251945-92-3 | |
| 货号 : | A887654 | |
| 分子式 : | C18H20N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 308.38 | |
| MDL号 : | MFCD12756289 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Derenofylline (SLV 320) is a potent, selective, and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM, and 398 nM for human A1, A3, and A2A receptors, respectively. Derenofylline mitigates cardiac fibrosis and reduces albuminuria in rats without affecting blood pressure [1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00568009 | - | Terminated(additional enrolmen... 展开 >>t criteria made patients' recruitment not feasible anymore) 收起 << | November 2008 | - | |
| NCT00160134 | Congestive Heart Failure | Phase 2 | Completed | - | Germany ... 展开 >> Site 1 Bad Nauheim, Germany 收起 << |
| NCT00744341 | Acute Decompensated Heart Fail... 展开 >>ure; Renal Dysfunction 收起 << | Phase 2 | Terminated(This study was stop... 展开 >>ped 29OCT2009 due to strategic drug development considerations) 收起 << | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.24mL 0.65mL 0.32mL |
16.21mL 3.24mL 1.62mL |
32.43mL 6.49mL 3.24mL |
| 参考文献 |
|---|