IC87201
产品说明书
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同义名 : | - |
| CAS号 : | 866927-10-8 | |
| 货号 : | A880304 | |
| 分子式 : | C13H10Cl2N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 309.15 | |
| MDL号 : | MFCD28160570 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | IC87201, at concentrations ranging from 500 to 1800 μM, does not block the interactions between the PDZ domains (PDZ1, PDZ2, PDZ3) of PSD-95 and nNOS-PDZ, nor does it attach to the standard PDZ ligand-binding sites. Instead, IC87201 targets the β-finger of nNOS-PDZ, resulting in an allosteric inhibition of the nNOS-PDZ/PSD-95-PDZ interaction. Additionally, when TAMRA-nNOS is used as a probe, IC87201 generates a significant fluorescence-based artefactual signal[1]. IC87201, at a concentration of 20 μM, inhibits the formation of cGMP that is stimulated by NMDA compared to the control, in neurons cultured from the hippocampus[2]. IC87201, at concentrations of 10 and 100 nM, mitigates the reduction in neurite outgrowth induced by NMDA/glycine. It also decreases NMDA-stimulated cGMP production in primary hippocampal neurons (DIV 14-21) in a dose-dependent manner, with an IC50 value of (2.7 \mu M). Furthermore, IC87201 enhances branching in these neurons at concentrations of 10-30 μM compared to neurons treated with the control[3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.23mL 0.65mL 0.32mL |
16.17mL 3.23mL 1.62mL |
32.35mL 6.47mL 3.23mL |
| 参考文献 |
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