LDHA-IN-4

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Chemical Structure| 1370290-34-8 同义名 : AZ-33; LDHA Inhibitor 33
CAS号 : 1370290-34-8
货号 : A879979
分子式 : C25H27N3O6S
纯度 : 99%+
分子量 : 497.56
MDL号 : MFCD29913759
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactate, utilizing NADH as a cofactor. It has been identified as a potential therapeutic target in the area of cancer metabolism. Az-33 is a LDHA inhibitor with an IC50 value of 0.5 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.05mL

2.01mL

1.00mL

20.10mL

4.02mL

2.01mL
参考文献

[1]Ward RA, Brassington C, Breeze AL, et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012;55(7):3285-3306