Cevipabulin

产品说明书

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Chemical Structure| 849550-05-6 同义名 : TTI-237
CAS号 : 849550-05-6
货号 : A859872
分子式 : C18H18ClF5N6O
纯度 : 98%
分子量 : 464.82
MDL号 : MFCD09832720
存储条件:

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Cevipabulin is a potent, synthetic small molecule, inhibits binding of vinblastine at the Vinca alkaloid site of the αβ-tubulin heterodimer.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.76mL

2.15mL

1.08mL

21.51mL

4.30mL

2.15mL

参考文献

[1]Ayral-Kaloustian S, Zhang N, Beyer C. Cevipabulin (TTI-237): preclinical and clinical results for a novel antimicrotubule agent. Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):443-7. doi: 10.1358/mf.2009.31.7.1410793.

[2]Beyer CF, Zhang N, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300.