同义名 :	-
	CAS号 :	409345-29-5
	货号 :	A854175
	分子式 :	C20H23NO3
	纯度 :	95%
	分子量 :	325.4
	MDL号 :	MFCD08690525
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

JNJ16259685 robustly and entirely suppresses the increase in intracellular Ca2+ levels triggered by glutamate (30 μM) at the rat mGlu1a receptor, with an IC50 of 3.24±1.00 nM. JNJ16259685 also impedes the glutamate-prompted elevation in intracellular Ca2+ levels at the rat mGlu5a receptor with an IC50 of 1.31±0.39 μM. Moreover, JNJ16259685 obstructs glutamate-induced Ca2+ mobilization at the human mGlu5 receptor with an IC50 of 28.3±11.7 μM. JNJ16259685 does not show any agonist activity at any of the group I mGlu receptors[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.07mL 0.61mL 0.31mL	15.37mL 3.07mL 1.54mL	30.73mL 6.15mL 3.07mL

参考文献
[1]Hodgson RA, Hyde LA, et al. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr;98(2):181-7. [2]Navarro JF, De Castro V, et al. JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. Eur J Pharmacol. 2008 May 31;586(1-3):217-20.