同义名 :	20 (S)-原人参三醇 ;20(S)-APPT; g-PPT; 20(S)-PPT; 20(S)-Protopanaxatriol
	CAS号 :	34080-08-5
	货号 :	A849617
	分子式 :	C30H52O4
	纯度 :	98%
	分子量 :	476.73
	MDL号 :	MFCD11041271
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs), and is also a LXRα inhibitor. (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs[2]. PPT((20S)-Protopanaxatriol) inhibited the LXRα-dependent transcription of lipogenic genes, such as sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase, and stearoyl CoA desaturase 1. Furthermore, LXRα-dependent triglyceride accumulation in primary mouse hepatocytes was significantly reduced by PPT[3]. PPT enhanced adipogenesis by increasing the expression of PPARgamma target genes such as aP2, LPL and PEPCK. Furthermore, PPT significantly increased expression of glucose transporter 4 (GLUT4). PPT can be developed as a PPARgamma (Peroxisome proliferator-activated receptor gamma) agonist for the improvement of insulin resistance associated with diabetes[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.10mL 0.42mL 0.21mL	10.49mL 2.10mL 1.05mL	20.98mL 4.20mL 2.10mL

参考文献

[2]Leung KW, Leung FP, Mak NK, Tombran-Tink J, Huang Y, Wong RN. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37 [3]Oh GS, Yoon J, Lee GG, Oh WK, Kim SW. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7 [4]Han KL, Jung MH, Sohn JH, Hwang JK. Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol Pharm Bull. 2006 Jan;29(1):110-3