TUG-891
产品说明书
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同义名 : | - |
| CAS号 : | 1374516-07-0 | |
| 货号 : | A844329 | |
| 分子式 : | C23H21FO3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 364.41 | |
| MDL号 : | MFCD22421654 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Fatty acids can be agonists for cell surface G protein–coupled receptors (GPCRs) to regulate metabolic and inflammatory processes. FFA4, a menber of free fatty acid (FFA) receptor family, belongs to GPCRs. TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor FFA4 with pEC50 of 7.22 for hFFA4 which is 288-fold more potent than hFFA1. In Ca2+ mobilization assays employing Flp-In T-REx 293 cells that had been engineered to express human FFA4 (hFFA4), TUG-891 potently produced concentration-dependent increases in intracellular Ca2+. Further, TUG-891 again potently produced concentration-dependent responses in the Ca2+ assays. Again in hFFA4-inducible Flp-In T-REx 293 cells, TUG-891 increased ERK phosphorylation in a clear, concentration-dependent manner. Internalization of hFFA4 was monitored in live cells at 5-minute intervals after treatment with TUG-891 (10 μM). Furthermore, TUG-891 was able to promote desensitization of the receptor-signaling response and phosphorylation of hFFA4. In 3T3-L1 mouse adipocytes model, treatment with TUG-891 (10 μM) produced a statistically significant increase of [3H]deoxyglucose uptake[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.74mL 0.55mL 0.27mL |
13.72mL 2.74mL 1.37mL |
27.44mL 5.49mL 2.74mL |
| 参考文献 |
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