TM5441
产品说明书
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同义名 : | - |
| CAS号 : | 1190221-43-2 | |
| 货号 : | A843529 | |
| 分子式 : | C21H17ClN2O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 428.82 | |
| MDL号 : | MFCD31382187 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TM5441 is an orally bioavailable PAI-1 inhibitor with an IC50 ranging from 13.9 to 51.1 μM, capable of inducing intrinsic apoptosis in various human cancer cell lines. TM5441 can alleviate cardiac hypertension and vascular senescence induced by Nω-nitro-l-arginine methyl ester[1][2]. TM5441 inhibits the proliferation of HT1080, HCT116, Daoy, MDA-MB-231, and Jurkat cells in a dose-dependent manner, with IC50 values ranging from 13.9 to 51.1 μM. It also dose-dependently increases caspase 3/7 activity in HT1080 and HCT116 cells. Furthermore, TM5441 enhances apoptosis in these cells and induces mitochondrial depolarization[1]. In mouse proximal tubular epithelial cells, TM5441 effectively inhibits the fibrosis and inflammatory marker mRNA expression induced by PAI-1, and reverses the inhibition of plasminogen activator activity induced by PAI-1[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.33mL 0.47mL 0.23mL |
11.66mL 2.33mL 1.17mL |
23.32mL 4.66mL 2.33mL |
