SM-324405
产品说明书
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同义名 : | - |
| CAS号 : | 677773-91-0 | |
| 货号 : | A839990 | |
| 分子式 : | C19H23N5O4 | |
| 纯度 : | 98% | |
| 分子量 : | 385.42 | |
| MDL号 : | MFCD30182295 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Toll-like receptors (TLR) are a family of type I transmembrane receptors essential for the innate immune response. SM-324405 is a TLR7 agonist with an EC50 of 50.1nM in a reporter gene assay using HEK293 cells expressing human TLR7. The half-life (T1/2) of SM-324405 in human plasma was 2.6min. SM-324405 induced type I interferon via TLR7 activation in human peripheral blood mononuclear cells with a minimum effective concentration of 10nM. In Brown Norway rats sensitized by ovalbumin, intratracheal administration with SM-324405 at 0.1 or 1mg/kg inhibited eosinophil influx into bronchoalveolar lavage fluid in a dose-dependent manner as compared to the control group, while systemic IFN induction was not observed in SM-324405-treated rats[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.59mL 0.52mL 0.26mL |
12.97mL 2.59mL 1.30mL |
25.95mL 5.19mL 2.59mL |
| 参考文献 |
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