同义名 :	-
	CAS号 :	96990-18-0
	货号 :	A829165
	分子式 :	C41H64O13
	纯度 :	95%
	分子量 :	764.94
	MDL号 :	MFCD11042256
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Momordin Ic (MI), a natural product isolated and purified from the fruits of Kochia scoparia (L.) Schrad., might represent a potential source of anticancer candidate, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAPK and PI3K-mediated iNOS and HO-1 pathways. Momordin Ic promoted the formation of autophagic vacuole and expression of Beclin 1 and LC-3 in a dose- and time-dependent manner[3]. Momordin Ic prevent cell invasion by inhibiting VCAM-1, ICAM-1, MMP-9 but inducing E-cadherin expression via p38 and JNK pathways[4]. MI inhibited cell proliferation with G0/1 phase cell cycle arrest in colon cancer cells. MI exerted an anti-tumor activity in colon cancer cells via SENP1/c-Myc signaling pathway[5]. MI, a new type of SENP1 inhibitor, reduces LPS-induced cellular inflammation by depressing SENP1 expression. Furthermore, MI-depressed Sp3 expression disturbed Sp3-nuclear factor (NF)-κB interaction and then alleviated LPS-induced cellular inflammation[6]. Momordin Ic, but not 20-hydroxyecdysone and oleanolic acid, had inhibitory effects on the production of inflammatory cytokines TNF-α and IL-6 in LPS-treated RAW264.7 macrophages[7].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.31mL 0.26mL 0.13mL	6.54mL 1.31mL 0.65mL	13.07mL 2.61mL 1.31mL

参考文献

[1]Wang J, Yuan L, et al. Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways. Apoptosis. 2013 Jun;18(6):751-65. [2]Kim NY, Lee MK, et al. Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J Med Food. 2005 Summer;8(2):177-83. [3]Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016 Jan;90:230-42 [4]Wang J, Liu Q, Xiao H, Luo X, Liu X. Suppressive effects of Momordin Ic on HepG2 cell migration and invasion by regulating MMP-9 and adhesion molecules: Involvement of p38 and JNK pathways. Toxicol In Vitro. 2019 Apr;56:75-83 [5]Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S. Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway. J Pharmacol Sci. 2021 Aug;146(4):249-258 [6]Zheng C, Li D, Zhan W, He K, Yang H. Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-κB interaction. Am J Transl Res. 2020 Nov 15;12(11):7439-7448 [7]Yoo SR, Jeong SJ, Lee NR, Shin HK, Seo CS. Quantification Analysis and In Vitro Anti-Inflammatory Effects of 20-Hydroxyecdysone, Momordin Ic, and Oleanolic Acid from the Fructus of Kochia scoparia. Pharmacogn Mag. 2017 Jul-Sep;13(51):339-344