LY2389575 HCl
产品说明书
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同义名 : | - |
| CAS号 : | 885104-09-6 | |
| 货号 : | A828145 | |
| 分子式 : | C15H16BrCl3N4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 438.58 | |
| MDL号 : | MFCD28133385 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | LY2389575 hydrochloride is a selective and non-competitive mGlu3 negative allosteric modulator (NAM) with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in the level of Mrc1. LY2389575 hydrochloride also independently amplifies the toxicity of amyloid beta (Aβ), which can be used in Alzheimer's disease research[1][2][3].At a concentration of 5 μM, treatment for 1 hour, LY2389575 hydrochloride induces elevated levels of Mrc1 in microglia[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.28mL 0.46mL 0.23mL |
11.40mL 2.28mL 1.14mL |
22.80mL 4.56mL 2.28mL |
