SZL P1-41
产品说明书
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同义名 : | - |
| CAS号 : | 222716-34-9 | |
| 货号 : | A796427 | |
| 分子式 : | C24H24N2O3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 420.52 | |
| MDL号 : | MFCD00711481 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SZL P1-41, a specific inhibitor of Skp2, attaches to the F-box domain of Skp2, inhibiting the association with Skp1 and the formation of the Skp2 SCF complex. Similar to the effects of Skp2 deficiency, SZL P1-41 enhances apoptosis/senescence mediated by p27 and disrupts glycolysis driven by Akt. It exhibits anti-tumor activities. At concentrations ranging from 5 to 20μM over a period of 24 hours, it leads to the induction of endogenous p27 protein expression in PC3 cells. Additionally, it prompts the expression of p21, another substrate of Skp2.[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.38mL 0.48mL 0.24mL |
11.89mL 2.38mL 1.19mL |
23.78mL 4.76mL 2.38mL |
| 参考文献 |
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