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产品说明书
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同义名 : | AMD-070; AMD 11070; X4P-001; AMD-11070 |
| CAS号 : | 558447-26-0 | |
| 货号 : | A792545 | |
| 分子式 : | C21H27N5 | |
| 纯度 : | 98+% | |
| 分子量 : | 349.47 | |
| MDL号 : | MFCD11977316 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02680782 | Healthy | Phase 1 | Terminated | - | United States, Florida ... 展开 >> Covance CRU, Inc. Daytona Beach, Florida, United States, 32117 收起 << |
| NCT03005327 | WHIM Syndrome | Phase 2 Phase 3 | Recruiting | August 2019 | United States, Florida ... 展开 >> University of South Florida Recruiting Saint Petersburg, Florida, United States, 33701 United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109 United States, Washington University of Washingington Medical Center Recruiting Seattle, Washington, United States, 98195 Australia, Victoria St. Vincent's Hospital Recruiting Fitzroy, Victoria, Australia, 3065 收起 << |
| NCT02823405 | Melanoma | Phase 1 | Recruiting | October 2017 | United States, Georgia ... 展开 >> Clinical Site Recruiting Atlanta, Georgia, United States, 30322 United States, Iowa Clinical Site Recruiting Iowa City, Iowa, United States, 52242 United States, Texas Clinical Site Recruiting Houston, Texas, United States, 77030 United States, Utah Clinical Site Recruiting Salt Lake City, Utah, United States, 84112 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.86mL 0.57mL 0.29mL |
14.31mL 2.86mL 1.43mL |
28.61mL 5.72mL 2.86mL |
| 参考文献 |
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