Marizomib

产品说明书

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Chemical Structure| 437742-34-2 同义名 : Salinosporamide A; NPI-0052; (-)-Salinosporamide A; MRZ; ML858
CAS号 : 437742-34-2
货号 : A792362
分子式 : C15H20ClNO4
纯度 : 99+%
分子量 : 313.78
MDL号 : MFCD16037703
存储条件:

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Marizomib, a natural product isolated and purified from marine bacteria Salinispora tropica and Salinispora arenicola, inhibits 20S proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.93mL

3.19mL

1.59mL

31.87mL

6.37mL

3.19mL

参考文献

[1]Harrison SJ, Mainwaring P, et al. Phase I Clinical Trial of Marizomib(NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results. Clin Cancer Res. 2016 Sep 15;22(18):4559-66.

[2]Richardson PG, Zimmerman TM, et al. Phase 1 study of marizomib in relapsed or relapsed and refractory multiple myeloma: NPI-0052-101 Part 1. Blood. 2016 Jun 2;127(22):2693-700.