ML406
产品说明书
 |
同义名 : | - |
| CAS号 : | 774589-47-8 | |
| 货号 : | A789739 | |
| 分子式 : | C20H20N2O4 | |
| 纯度 : | 98+% | |
| 分子量 : | 352.38 | |
| MDL号 : | MFCD06004413 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BioA (7, 8-diaminopelargonic acid (DAPA) synthase) catalyzes the reversible transamination between KAPA and DAPA, the second-to-last step of biotin synthesis in Mycobacterium tuberculosis (TB). ML406 is a small molecule probe that exhibits antituberculous activity by inhibiting BioA with an IC50 of 30 nM. ML406 has an IC50 of 155 nM and an EC50 of 9.3 μM with best cellular activity tested in a TB strain with limited biotin formation relative to wild type confirming mechanism of action[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.84mL 0.57mL 0.28mL |
14.19mL 2.84mL 1.42mL |
28.38mL 5.68mL 2.84mL |
| 参考文献 |
|---|