同义名 :	-
	CAS号 :	34221-41-5
	货号 :	A783726
	分子式 :	C16H14O4
	纯度 :	95%
	分子量 :	270.28
	MDL号 :	MFCD00075719
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Echinatin is a chalcone isolated from the Chinese herbal medicine Gancao with hepatoprotective and anti-inflammatory effects[3]. Administration of echinatin obviously inhibits NLRP3 inflammasome activation and ameliorates LPS-induced septic shock and dextran sodium sulfate-induced (DSS-induced) colitis in mice. Moreover, echinatin exerted favorable pharmacological effects on liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis (NASH)[4]. Echinatin induced apoptosis and autophagy through inactivation of AKT/mTOR signaling pathway, whereas constitutive activation of AKT significantly abrogated these effects. Furthermore, echinatin had a significant antitumor effect in the tumor xenograft model and markedly suppressed cell migration and invasion abilities of ESCC (Esophageal squamous cell carcinoma) cells in a dose-dependent manner[5]. Echinatin exerted its protective effect against MI/R (myocardial ischemic/reperfusion) injury at least partially by suppressing the Hippo/YAP signaling pathway[6]. Echinatin mitigates H2O2-induced oxidative damage and apoptosis in HLECs (Human lens epithelial B3 cells) via the Nrf2/HO-1 pathway, suggesting that Ech may be a potential drug for the treatment of cataracts[7].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.70mL 0.74mL 0.37mL	18.50mL 3.70mL 1.85mL	37.00mL 7.40mL 3.70mL

参考文献

[1]Fu Y, Chen J, et al. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem. 2013 Nov 15;141(2):1063-71. [2]Inoue B, Inaba K, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54. [3]Liang M, Li X, Ouyang X, Xie H, Chen D. Antioxidant Mechanisms of Echinatin and Licochalcone A. Molecules. 2018 Dec 20;24(1):3 [4]Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X. Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. JCI Insight. 2021 Jan 25;6(2):e134601 [5]Hong P, Liu QW, Xie Y, Zhang QH, Liao L, He QY, Li B, Xu WW. Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. Cell Death Dis. 2020 Jul 13;11(7):524 [6]Niu J, Li Y, Song X, Liu Y, Li Y, Li Y. Cardioprotective Effect of Echinatin Against Ischemia/Reperfusion Injury: Involvement of Hippo/Yes-Associated Protein Signaling. Front Pharmacol. 2021 Jan 11;11:593225 [7]Ran H, Liu H, Wu P. Echinatin mitigates H2O2-induced oxidative damage and apoptosis in lens epithelial cells via the Nrf2/HO-1 pathway. Adv Clin Exp Med. 2021 Nov;30(11):1195-1203