(-)-Maackiain

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Chemical Structure| 2035-15-6 同义名 : 高丽槐素
CAS号 : 2035-15-6
货号 : A783235
分子式 : C16H12O5
纯度 : 99%+
分子量 : 284.26
MDL号 : MFCD00270457
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (-)-Maackiain is a phytoalexin isolated and purified from the flowers of Maackia amurensis Rupr.et Maxim., shows significant growth inhibitory action on the growth of the human lymphoblastoid cell lines Molt and Raji. (-)-Maackiain is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene, and shows a strong larvicidal effect against 4th instar larvae of Aedes aegypti(LC50=21.95±1.34ug/mL).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
参考文献

[1]Jang SM, Bae SH, et al. Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats. Xenobiotica. 2015;45(12):1092-104.

[2]Nariai Y, Mizuguchi H, et al. Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells. J Biol Chem. 2015 Nov 6;290(45):27393-402.