Futibatinib
产品说明书
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同义名 : | TAS-120 |
| CAS号 : | 1448169-71-8 | |
| 货号 : | A773884 | |
| 分子式 : | C22H22N6O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 418.45 | |
| MDL号 : | MFCD29037352 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
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| 描述 | Futibatinib, also referred to as TAS-120, is an orally administered inhibitor of FGFR that is both highly selective and irreversible. It demonstrates IC50 values of 3.9, 1.3, 1.6, and 8.3 nM for FGFRs 1 through 4, respectively. Futibatinib effectively inhibits both the mutant and wild-type forms of FGFR2, with comparable IC50 values (for wild-type FGFR2, the IC50 is 0.9 nM; for V5651, it ranges from 1 to 3 nM; for N550H, it is 3.6 nM; and for E566G, it is 2.4 nM)[1][2][3]. Futibatinib, known by its research name TAS-120, forms a covalent bond with the conserved cysteine residue located in the P-loop within the ATP-binding site of FGFR[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.39mL 0.48mL 0.24mL |
11.95mL 2.39mL 1.19mL |
23.90mL 4.78mL 2.39mL |
| 参考文献 |
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